Comparative Study on the Periodontal Parameters Used in Diagnosing Periodontitis in Puerperae and Periodontitis' Relationship with the Birth of Preterm Infants: A Case-Control Study.

To compare different criteria for the diagnosis of periodontitis and to evaluate the association of this condition with prematurity, this case-control study was conducted on 283 mothers of infants, divided into two groups based on gestational age (cases: <37 weeks, controls: ≥37 weeks), with 71 cases and 212 controls. The periodontal evaluation included probing depth (PD), clinical attachment level (CAL), plaque index, and bleeding on probing (BOP). Participants were classified regarding periodontitis per 14 criteria based on different periodontal parameters. The criterion selected as the gold standard was the presence of at least four teeth with one or more sites with a PD ≥ 4 mm, CAL ≥ 3 mm, and BOP at the same site. The prevalence of periodontal disease ranged from 8.1% to 55.1%. Moreover, compared to the gold standard, the sensitivities of the other criteria were 100%, while specificity ranged from 50.4% to 96.4%. Periodontitis, defined by six of the selected criteria, was associated with prematurity after multivariate adjustment, with OR ranging from 1.85 to 2.69 and 95% CI from 1.01 to 5.56; one of them was the gold standard mentioned above. Measurements using the clinical parameters of PD, CAL, and bleeding at the same site (criteria 5, 6, 7, 8), CPI (criterion 10), and at least four teeth with a PD ≥ 4 mm and CAL ≥ 3 mm (criterion 11) to define periodontitis showed a statistically significant association (p < 0.05). Given this study's limitations, we can conclude that the diagnostic criteria for a periodontitis definition using a PD ≥ 4 mm and CAL ≥ 3 mm in two or more teeth, with BOP at the same site, seem stronger when detecting an association between periodontitis and prematurity.

Fusobacterium nucleatum and Prevotella in women with periodontitis and preterm birth

Background: Studies try to explain the hypothesis that maternal periodontitis may be associated with preterm birth. Material and methods: This is a case-control study with 120, 40 cases (gestational age <37 weeks) and 80 controls (gestational age ≥37 weeks), that were submitted to the clinical periodontal examination and subgingival biofilm collection. Bacterial DNA of subgingival biofilm was performed and processed by qPCR. Results: Periodontitis was statistically significant in the Case group (35%) when compared to the Control group (11.2%) and Gingival Bleeding Index (GBI), sites with PS ≥ 4mm and sites with CAL ≥ 5mm were statistically higher in the Case group (p < 0.05). The proportions of Pi (p = 0.026) and Fn (p = 0.041) of subgingival biofilm were higher in the Case group. A greater number of sites with PS ≥ 4mm (r = -0.202; p = 0.026) and CAL ≥ 5mm (r = -0.322; p < 0.001) were correlated to lower gestational age. Conclusions: Periodontitis, preterm delivery, and/or low birth weight may have a possible relationship based on clinical parameters and the ratio of Pi and Fn at periodontal sites. (AU)

Human Papillomavirus Modulates Matrix Metalloproteinases During Carcinogenesis: Clinical Significance and Role of Viral Oncoproteins.

Human papillomavirus (HPV) infections are associated with cervical cancer and other anogenital cancers. Despite progresses in HPV vaccination and screening, these cancers still show high incidence and mortality, requiring improved prognostic markers and tailored therapies. This review addresses the role of Matrix metalloproteinases (MMPs) in HPV-induced cancers and the modulation of MMP expression by HPV oncoproteins. Scientific literature indexed in PubMed and ScienceDirect about Human papillomavirus modulates matrix metalloproteinases was retrieved and critically analyzed, to obtain an overview of expression patterns and their implications for carcinogenesis and patient prognosis. Matrix metalloproteinases such as MMP1, MMP9 and MMP13 have been associated with patient prognosis in HPV-induced cancers and play a major role in the degradation of the extracellular matrix, tumor invasion and metastasis. The HPV E2 and E7 oncoproteins regulate MMP expression via AKT, MEK/ERK and AP-1 signaling among other mechanisms. Increased expression of MMPs is associated with cancer progression and poor prognosis in multiple HPV-induced cancers, suggesting their potential use as prognostic markers. The identification of specific signaling pathways that mediate MMP regulation by HPV is essential for developing efficient new cancer therapies.

Oral Manifestation of Pseudomonas Aeruginosa in a Kidney Transplant Recipient with Cytomegalovirus Co-Infection: a Case Report / Manifestação Oral por Pseudomonas Aeruginosa em Paciente Transplantado Renal com Coinfecção por Citomegalovírus: Relato de Caso

Opportunistic viral infections are common in kidney transplant recipients. They are mainly caused by cytomegalovirus, which in addition to causing infection, can increase immunosuppression and facilitate colonization by other pathogens. This study presents the clinical case report of a kidney transplant recipient affected by cytomegalovirus who presented oral lesions caused by Pseudomonas aeruginosa. A 55-year-old male patient with gingival burning and chewing pain presented whitish areas in his gums in the region from element 22 to 24, surrounded by erythematous areas. Culture examination and biopsy revealed the presence of the bacteria P. aeruginosa, confirmed by blood culture. After seven days of antibiotic therapy, a significant improvement was observed in his oral condition. Thus, it was concluded that the oral cavity was the infection site in this kidney transplant patient, demonstrating the importance of a dentist in a multidisciplinary team to perform early diagnosis of oral lesions, and thus prevent possible systemic complications that may culminate in graft rejection. (AU)

Infecções virais oportunistas são comuns em transplantados renais, principalmente causadas pelo citomegalovírus, que além de causar infecção, pode aumentar a imunossupressão e facilitar a colonização por outros patógenos. Nós apresentamos aqui o relato de caso clínico de um transplantado renal acometido por citomegalovírus que apresentou lesões bucais causadas por P. aeruginosa. Paciente do sexo masculino, 55 anos, com ardência gengival e dor à mastigação, apresentava áreas esbranquiçadas em gengiva na região do 22 ao 24 circundadas por áreas eritematosas. Exame de cultura e biópsia revelaram a presença da bactéria P. aeruginosa, confirmada na hemocultura. Após sete dias de antibioticoterapia, observamos melhora significativa da condição bucal. Assim, concluímos que a cavidade bucal foi o sítio da infecção no paciente transplantado renal demonstrando a importância do dentista em equipe multidisciplinar para realizar diagnóstico precoce de lesões bucais e assim prevenir possíveis complicações sistêmicas que possam culminar com a rejeição do enxerto. (AU)

Fatores associados ao perfil psicossocial de mulheres durante o pré ­ natal / Factors associated with women's psychosocial profile during prenatal

Objetivo: analisar os fatores associados ao perfil psicossocial de mulheres durante o pré-natal no Hospital Universitário ­ Unidade Materno Infantil da Universidade Federal do Maranhão ­ HUUFMA. Métodos: estudo transversal realizado com 160 gestantes sem limite de faixa etária, atendidas no Ambulatório de Obstetrícia do HUUFMA no período de março a outubro de 2017. A avaliação do perfil psicossocial foi mensurada por meio do Prenatal Psychosocial Profile (PPP-VP). Resultados: a maioria das gestantes, cerca de 41,25% (66), possui somente o Ensino Médio completo, faixa etária de 15 a 35 anos , cerca de 65,66% (105), no último trimestre gestacional 46,25% (74), a maior parte primigesta, 60% (96), com menos de seis consultas pré-natais realizadas, 67,52% (108). Quanto ao trimestre gestacional, não houve significância estatística com os constructos do PPP-VP, relativo à paridade, as multíparas foram as que mais evidenciaram estresse e o teste de Tukey demonstrou que as multíparas tiveram mais estresse quando comparada com as nulíparas. Conclusão: é pertinente inferir que, em relação ao trimestre gestacional, não houve influência relativa aos constructos do perfil psicossocial, porém ao se relacionar paridade, a situação contrária foi observada, principalmente em multíparas, onde o maior número de partos refletia diretamente no nível desajustado do estresse, sendo assim é necessária uma maior atenção a essas questões para uma assistência pré-natal adequada (AU)

Objective: analyze the factors associated with the psychosocial profile of women during prenatal care at the University Hospital ­ Maternal-Child Unit of the Federal University of Maranhão ­ HUUFMA. Methods: a cross-sectional study conducted with 160 pregnant women without age limit assisted at the HUUFMA Obstetrics Outpatient Clinic from March to October 2017. The assessment of the psychosocial profile was measured using the Prenatal Psychosocial Profile (PPP-VP). Results: most pregnant women, about 41.25% (66) had only completed high school; aged from 15 to 35 years old, about 65.66% (105); in the last gestational trimester 46.25% (74); most of them primigravid, 60% (96); with less than six prenatal appointments performed 67.52% (108). As for the gestational trimester, there was no statistical significance with the PPP-VP constructs; concerning parity, multiparas were the ones who showed more stress, and the Tukey test showed that this group had more stress when compared to nulliparas. Conclusion: it is pertinent to infer that about the gestational trimester, there was no influence on the constructs of the psychosocial profile, but when relating parity, the opposite situation was observed, especially in multiparous women, in which the greater number of births directly reflected in the maladjusted level of stress. Greater attention is necessary to these issues for adequate prenatal care

Fatores associados ao perfil psicossocial de mulheres durante o pré­natal / Factors associated with women's psychosocial profile during prenatal

RESUMO: Objetivo: analisar os fatores associados ao perfil psicossocial de mulheres durante o pré-natal no Hospital Universitário ­ Unidade Materno Infantil da Universidade Federal do Maranhão ­ HUUFMA. Métodos: estudo transversal realizado com 160 gestantes sem limite de faixa etária, atendidas no Ambulatório de Obstetrícia do HUUFMA no período de março a outubro de 2017. A avaliação do perfil psicossocial foi mensurada por meio do Prenatal Psychosocial Profile (PPP-VP). Resultados: a maioria das gestantes, cerca de 41,25% (66), possui somente o Ensino Médio completo, faixa etária de 15 a 35 anos , cerca de 65,66% (105), no último trimestre gestacional 46,25% (74), a maior parte primigesta, 60% (96), com menos de seis consultas pré-natais realizadas, 67,52% (108). Quanto ao trimestre gestacional, não houve significância estatística com os constructos do PPP-VP, relativo à paridade, as multíparas foram as que mais evidenciaram estresse e o teste de Tukey demonstrou que as multíparas tiveram mais estresse quando comparada com as nulíparas. Conclusão: é pertinente inferir que, em relação ao trimestre gestacional, não houve influência relativa aos constructos do perfil psicossocial, porém ao se relacionar paridade, a situação contrária foi observada, principalmente em multíparas, onde o maior número de partos refletia diretamente no nível desajustado do estresse, sendo assim é necessária uma maior atenção a essas questões para uma assistência pré-natal adequada. (AU)

ABSTRACT: Objective: analyze the factors associated with the psychosocial profile of women during prenatal care at the University Hospital ­ Maternal-Child Unit of the Federal University of Maranhão ­ HUUFMA. Methods: a cross-sectional study conducted with 160 pregnant women without age limit assisted at the HUUFMA Obstetrics Outpatient Clinic from March to October 2017. The assessment of the psychosocial profile was measured using the Prenatal Psychosocial Profile (PPP-VP). Results: most pregnant women, about 41.25% (66) had only completed high school; aged from 15 to 35 years old, about 65.66% (105); in the last gestational trimester 46.25% (74); most of them primigravid, 60% (96); with less than six prenatal appointments performed 67.52% (108). As for the gestational trimester, there was no statistical significance with the PPP-VP constructs; concerning parity, multiparas were the ones who showed more stress, and the Tukey test showed that this group had more stress when compared to nulliparas. Conclusion: it is pertinent to infer that about the gestational trimester, there was no influence on the constructs of the psychosocial profile, but when relating parity, the opposite situation was observed, especially in multiparous women, in which the greater number of births directly reflected in the maladjusted level of stress. Greater attention is necessary to these issues for adequate prenatal care.

Effect of the intra-alveolar administration of dexamethasone on swelling, trismus, and pain after impacted lower third molar extraction: a randomized, double-blind clinical trial

Background: To evaluate the efficacy of intra-alveolar administration of dexamethasone 4 mg in the control of edema, trismus, and pain resulting from the extraction of impacted lower third molars and the drug permeability through the oral mucosa by in silico prediction. Material and Methods: The randomized, double-blind, split-mouth clinical trial included patients who had both impacted lower third molars in equivalent positions. Hemiarches were divided into control side when dexamethasone was administered orally and experimental side when dexamethasone was administered using the intra-alveolar route. Patients were evaluated considering edema, trismus, and pain. The permeability of dexamethasone through the oral mucosa was assessed by in silico prediction. Student’s t-test was selected for comparative analysis of edema and trismus, and the chi-square test analyzed the distribution of postoperative pain between the sides. Results: There were no significant differences between the routes of administration in measuring symptoms between the pre and postoperative times (p>0.05). In silico prediction suggested that dexamethasone molecular characteristics facilitate intra-alveolar administration. Conclusions: Intra-alveolar administration had similar efficacy to oral administration in controlling symptoms of post-surgical inflammation of impacted lower third molars.(AU)

Análise da casuística da condição bucal de pacientes da clínica cirúrgica de um hospital universitario / Analysis of cases of oral health condition of patients of surgical clinic of the hospital university / Análisis de la casuística del estado oral de pacientes de la clínica quirúrgica de un hospital universitario

Resumo Introdução e objetivo: A presença do cirurgião dentista na equipe de saúde multidisciplinar de atendimento hospitalar é essencial através da sua atuação em procedimentos que se fazem necessários para manutenção da saúde bucal e geral do paciente. Identificar os aspectos odontológicos dos pacientes, determinar a condição bucal e as lesões mais prevalentes na cavidade bucal dos pacientes internados, na Clínica Cirúrgica do Hospital Universitário da UFMA, Unidade Presidente Dutra. Materiais e métodos: Estudo descritivo, com base em dados secundários de uma amostra com 1475 pacientes internados na clínica cirúrgica do hospital no ano de 2017. Os dados coletados foram: gênero, idade, motivo da internação, tempo de internação, processos patológicos na cavidade bucal, presença e condição de prótese dental, procedimentos realizados e encaminhamentos. Os resultados foram analisados quantitativamente e empregado o teste do qui-quadrado (α=0,05). Resultados: Em relação aos achados clínicos, a prevalência de cárie foi de 11,32% dos pacientes, enquanto o cálculo/ biofilme foi detectado em 26,92%, a mobilidade dentária em 7,46% e raiz residual em 20% dos pacientes A higiene oral regular foi a mais prevalente com 73,54%, seguida por higiene oral deficiente 19,74% e boa com 6,72%. Conclusão: Os resultados mostram que as alterações bucais são frequentes na cavidade bucal de pacientes hospitalizados, com baixa frequência de boa higiene oral. Assim, a atuação da equipe de odontologia na equipe multiprofissional é fundamental por caracterizar essa população e relacionar com as variáveis clinicas, atendendo nos casos que é necessário e informando a importância da manutenção de uma boa saúde bucal.

Abstract Introduction and objective: The presence of the dental surgeon in the multidisciplinary health care team is essential through their performance in procedures that are necessary to maintain the patient's general and oral health. To identify the dental aspects of the patients, to determine the oral condition and the most prevalent lesions in the oral cavity of the hospitalized patients, at the Clinic Surgical Hospital of the University Hospital of UFMA, Presidente Dutra Unit. Methods: It is a descriptive study, based on secondary data and quantitative analysis. The sample consisted of patients hospitalized at the Hospital's surgical clinic. The obtained data were analyzed quantitatively, presented in absolute and percentage numbers, and the chi-square test (α = 0.05) was used. Results: Regarding the clinical findings, caries was prevalent in 11.32% of the patients. The calculation / biofilm was detected in 26.92%. Dental mobility had a prevalence of 7.46%. The residual root was present in 20% of patients Regular oral hygiene was prevalent with 73.54%, followed by poor oral hygiene 19.74% and good with 6.72%. Conclusion: The results show that dental changes are frequent in the oral cavity of hospitalized patients, with low fertility of good oral hygiene. Thus, the performance of the dentistry team in the patient care team is fundamental to characterize this population with the findings found through clinical examination, attending to cases that are necessary and informing the importance of maintaining good oral health.

Resumen Introducción y objetivo: La presencia del cirujano dentista en el equipo de salud multidisciplinario de atención hospitalaria es esencial a través de su actuación en procedimientos que se hacen necesarios para el mantenimiento de la salud bucal y general del paciente. Identificar los aspectos odontológicos de los pacientes, determinar la condición bucal y las lesiones más prevalentes en la cavidad bucal de los pacientes internados, en la Clínica Quirúrgica del Hospital Universitario de la UFMA, Unidad Presidente Dutra. Materiales y métodos: La investigación fue realizada a través de un estudio descriptivo, con base en datos secundarios y análisis cuantitativo. La muestra fue compuesta por 1475 pacientes internados en la clínica quirúrgica del Hospital en el año 2017. Los datos obtenidos fueron analizados cuantitativamente, presentados en números absolutos y porcentuales, y empleado el test del chi-cuadrado (α = 0,05). Resultados: En relación a los hallaz-gos clínicos, la prevalencia de caries fue del 11,32% de los pacientes. El cálculo / biopelícula fue detectado en el 26,92%. La movilidad dental tuvo una prevalencia del 7,46%. La raíz residual estuvo presente en el 20% de los pacientes La higiene oral regular fue prevalente con el 73,54%, seguida por higiene oral deficiente 19,74% y buena con el 6,72%. Conclusión: Los resultados muestran que las alteraciones bucales son frecuentes en la cavidad bucal de pacientes hospitalizados, con baja frecuencia de buena higiene oral. Así, la actuación del equipo de odontología en el equipo multiprofesional es fundamental por caracterizar esa población y relacionar con las variables clínicas, atendiendo en los casos que es necesario e informando la importancia del mantenimiento de una buena salud bucal.

Aspects of dental care for patients hospitalized in a medical clinic from a university hospital / Aspectos da assistência odontológica a pacientes internados em clínica médica de um hospital universitário

INTRODUCTION: The current context of multiprofessional approach in health is based on quality of care and patient safety, with the key contribution of the dentist in the hospital team to improve the health of hospitalized patients. OBJECTIVE: To characterize the systemic and buccal profile of patients treated in a medical clinic of a University Hospital from the Brazilian Public Health System, aiming to provide information for guiding dental care in the multidisciplinary attendance in the hospital setting. METHODS: Retrospective observational study carried out on 104 clinical records with data collection about general characteristics, systemic alterations, habits, oral situation and dental treatments of hospitalized patients attended by the dentist. RESULTS: There was a high frequency of hypertensive patients (36.5%) and with cardiac problems (33.6%). A significant association between diabetes (60%) and hypertension (50%) in the age group from 60 to 75 years of age was observed. For most patients, the frequency of oral hygiene was less than three times a day (54.3%), without flossing (85.7%). Biofilm (73.3%), dental calculus (70.5%), prosthesis use (25.7%), with poor hygiene (14.3%) and prosthetic stomatitis (8.6%) were recorded. Among the treatments performed by dentist, basic periodontal therapy (71.4%) and exodontia (39%) were noteworthy. CONCLUSION: The high frequency of biofilm presence, dental calculus, prosthesis with poor hygiene and basic periodontal therapy performed during the hospitalization denote the need for dental care with preventive activities.

INTRODUÇÃO: O contexto atual de abordagem multiprofissional em saúde fundamenta-se na qualidade do atendimento e segurança ao paciente, com contribuição importante do cirurgião-dentista na equipe hospitalar para melhoria de saúde dos hospitalizados. OBJETIVO: Caracterizar o perfil sistêmico e bucal de pacientes atendidos em clínica médica de um Hospital Universitário do Sistema de Saúde Pública do Brasil, visando fornecer subsídios no direcionamento da assistência odontológica ao atendimento multidisciplinar em âmbito hospitalar. MÉTODOS: Foi realizado estudo observacional retrospectivo em 104 fichas clínicas com coleta de dados sobre características gerais, alterações sistêmicas, hábitos, situação bucal e tratamentos odontológicos de pacientes internados, atendidos pelo odontólogo. RESULTADOS: Verificou-se alta frequência de pacientes hipertensos (36,5%) e com problemas cardíacos (33,6%). Observou-se associação significativa de diabetes (60%) e hipertensão (50%) na faixa etária de 60 a 75 anos de idade. Para a maioria dos pacientes, a higiene bucal foi realizada menos que três vezes ao dia (54,3%), sem uso de fio dental (85,7%). Biofilme (73,3%), cálculo dental (70,5%), uso de próteses (25,7%), com higiene deficiente (14,3%), e estomatite protética (8,6%) foram registradas. Dentre os tratamentos realizados, destacam-se a terapia básica periodontal (71,4%) e exodontias (39%). CONCLUSÃO: A alta frequência de presença de biofilme, cálculo dental, próteses com higiene deficiente e a terapia básica periodontal executada durante o período de internação denotam a necessidade de atuação odontológica com atividades preventivas.

Relação entre o estresse e a autoestima de gestantes durante o pré-natal / Relationship between stress and self-esteem of pregnant women during prenatal care

RESUMO: Objetivo: analisar os componentes do perfil psicossocial de gestantes durante o pré-natal. Métodos: estudo quantitativo, analítico, realizado com 160 gestantes, entre 14 e 47 anos de idade, atendidas num Hospital de referência do Maranhão, em 2017. Resultados: a maioria das gestantes tinha entre 19 a 35 anos de idade (48,75%); realizaram de 0 a 5 consultas de pré-natal (40,65%) e eram nulíparas (43,13%). A análise de regressão linear evidenciou a influência do estresse devido a problemas financeiros e relacionados à família, os itens que mais explicaram o constructo autoestima foram sentir que não é um fracasso e sentir-se satisfeita consigo mesma; A correlação de Pearson do estresse e autoestima foi negativa e com influência significativamente forte. Conclusão: o estresse dentre os fatores psicossociais é o que mais influencia para alterações no pré-natal provavelmente na autoestima, pois quando relacionado com estresse evidenciou relação negativa. (AU)

ABSTRACT: Objective: Analyzing the components of the psychosocial profile of pregnant women during prenatal care. Methods: a quantitative and analytical study performed with 160 pregnant women between the ages of 14 and 47 assisted at a reference hospital in Maranhão, in 2017. Results:the majority of pregnant women were between 19 and 35 years of age (48.75%); attended to 0-5 prenatal appointments (40.65%), and were nulliparous (43.13%).The linear regression analysis evidenced the influence of stress due to financial and family-related problems; the items that most explained the construct of self-esteem were feeling that they are not a failure and feeling satisfied with themselves; Pearson's correlation of stress and self-esteem was negative and had a significantly stronginfluence. Conclusion: the stress among the psychosocial factors is the one that most influences prenatal changesprobably in self-esteem because when related to stress it showed a negative relation. (AU)

Hyperglycaemia and factors associated with dental caries in immediate postpartum women.

Objective: Dental caries and hyperglycaemia share common risk factors. The aim of this study was to identify factors associated with dental caries in women in the immediate postpartum period. It also verified whether women with hyperglycaemia presented more dental caries than those with normal glycaemia.Material and Methods: This cross-sectional study was performed on 297 women recruited from a teaching hospital in Brazil (from October 2011 to November 2012). Dental caries and oral biofilm were evaluated by oral examination. The blood glucose was accessed by Haemoglobin A1c test. Information on socioeconomic characteristics, harmful habits and oral health habits was also gathered.Results: More than half (66%) of the women had carious lesions. Univariate analysis showed no association between hyperglycaemia and dental caries (p = .39). The hierarchical logistic regression model showed that the following variables were associated with dental caries: maternal education level ≤8 years (ORadjusted = 2.40 [CI 1.19-4.82]), previous children (ORadjusted = 1.81 [CI 1.08-3.03), use of dental floss (ORadjusted = .48 [CI 0.27-0.86]), and visible plaque index ≥30% (ORadjusted = 1.83 [CI 1.05-3.20]).Conclusions: These findings call attention to the need to implement effective public policies directed at avoiding tooth decay in pregnancy and in the postpartum period.

Detection of periodontal pathogens in mothers of preterm birth and/or low weight

BACKGROUND: The present study aims to estimate the possible relationship between periodontal pathogens in the oral cavity and the birth of Preterm Birth (PTB) and/or Low Birth Weight (LBW). MATERIAL AND METHODS: It's a case- control study with the subgengival biofilm samples were collected from four sites up deeper until 48 hours postpartum and were processes by Polymerase Chain Reaction (PCR) for presence the periodontal pathogens Prevotella intermedia (Pi), Fusobacterium nucleatum (Fn), Porphyromonas gingivalis (Pg), Treponema denticola (Td), Tannerella forsythia (Tf) e Aggregatibacter actinomycetemcomitans (Aa). The mothers were divided into case grup (babies weighing < 2500 g and/or gestational age < 37 weeks) and control group (babies weighing ≥ 2500 g and gestational age ≥ 37 weeks). Chi-square test and the measure of association obtained by Odds Ratio (OR) were used to estimate the association between the variables. RESULTS: Microbial analyses results showed no significant association between PTB and LBW with most periodontal pathogens in the oral cavity, even with association with the clinical presence of periodontitis. CONCLUSIONS: given the high presence of periodontal pathogens in the biofilm subgengival of recent mothers, it is suggested that the findings of this research serve as the basis for future studies on the pathophysiology involved in the relationship between periodontitis and PTB and/or LBW

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[Characterization of oral maxillofacial lesions resulting from physical aggression: differences between genders]. / Caracterização de lesões bucomaxilofaciais decorrentes de agressão física: diferenças entre gênero.

In developed countries, violence is the main cause of oral maxillofacial (OMF) injuries. In Brazil, there are scant records of such lesions. The scope of this study was to detail the OMF injuries resulting from physical aggression in a capital of the Brazilian northeast and analyze gender differences. The Forensic Medicine Institute of São Luís, state of Maranhão, featured 15,847 reports, which occurred in 2012, and they were investigated. Socioeconomic, demographic data and OMF characteristics were analyzed. The Chi-square and Fisher's Exact tests were applied to assess gender differences. Of the cases examined, 1977 were OMF. Female victims, aged 20-59, dark-skinned, without a partner and maids were the most affected. Ecchymosis-type lesions, in the mouth and lip regions arising from the use of blunt instruments, causing permanent functional impairment, were the most prevalent in women (P < 0.05), whereas dental fracture and contusion arising from sharp instruments causing permanent deformity, occupational disability, and threat to life were detected in men (P < 0.05). The conclusion drawn is that the incidence of OMF due to physical aggression is high in São Luís, state of Maranhão, and although women are the most affected, the OMF in men are more severe.

Em países desenvolvidos, a violência é a principal causa de lesões bucomaxilofaciais (LBMF). No Brasil, há poucas evidências sobre tais lesões. Objetivou-se caracterizar as LBMF resultantes de agressão física em uma capital do nordeste brasileiro e analisar diferenças entre gêneros. Foram investigados 15.847 laudos do Instituto Médico Legal de São Luís/MA, ocorridos em 2012. Coletaram-se dados socioeconômicos, demográficos e características das LBMF. Utilizaram-se os testes Qui-quadrado e Exato de Fisher para avaliar diferenças entre gêneros. Dos casos periciados, 1977 eram LBMF. Vítimas do sexo feminino, com 20-59 anos de idade, cor parda, sem companheiro e empregadas foram mais afetadas. Lesões do tipo equimose, nas regiões bucinadora e labial, decorrentes do uso de instrumentos contundentes, ocasionando debilidade funcional permanente foram mais incidentes em mulheres (P < 0,05), ao passo que fratura dental, ferida contusa e perfurocontusa, decorrentes de instrumentos cortantes e perfurocontundentes, ocasionando deformidade permanente, incapacidade ocupacional e perigo de vida, em homens (P < 0,05). Conclui-se que a incidência de LBMF decorrente de agressão física é alta em São Luís, MA, e, embora as mulheres sejam mais acometidas, as LBMF em homens são mais severas.

Caracterização de lesões bucomaxilofaciais decorrentes de agressão física: diferenças entre gênero / Characterization of oral maxillofacial lesions resulting from physical aggression: differences between genders

Resumo Em países desenvolvidos, a violência é a principal causa de lesões bucomaxilofaciais (LBMF). No Brasil, há poucas evidências sobre tais lesões. Objetivou-se caracterizar as LBMF resultantes de agressão física em uma capital do nordeste brasileiro e analisar diferenças entre gêneros. Foram investigados 15.847 laudos do Instituto Médico Legal de São Luís/MA, ocorridos em 2012. Coletaram-se dados socioeconômicos, demográficos e características das LBMF. Utilizaram-se os testes Qui-quadrado e Exato de Fisher para avaliar diferenças entre gêneros. Dos casos periciados, 1977 eram LBMF. Vítimas do sexo feminino, com 20-59 anos de idade, cor parda, sem companheiro e empregadas foram mais afetadas. Lesões do tipo equimose, nas regiões bucinadora e labial, decorrentes do uso de instrumentos contundentes, ocasionando debilidade funcional permanente foram mais incidentes em mulheres (P < 0,05), ao passo que fratura dental, ferida contusa e perfurocontusa, decorrentes de instrumentos cortantes e perfurocontundentes, ocasionando deformidade permanente, incapacidade ocupacional e perigo de vida, em homens (P < 0,05). Conclui-se que a incidência de LBMF decorrente de agressão física é alta em São Luís, MA, e, embora as mulheres sejam mais acometidas, as LBMF em homens são mais severas.

Abstract In developed countries, violence is the main cause of oral maxillofacial (OMF) injuries. In Brazil, there are scant records of such lesions. The scope of this study was to detail the OMF injuries resulting from physical aggression in a capital of the Brazilian northeast and analyze gender differences. The Forensic Medicine Institute of São Luís, state of Maranhão, featured 15,847 reports, which occurred in 2012, and they were investigated. Socioeconomic, demographic data and OMF characteristics were analyzed. The Chi-square and Fisher's Exact tests were applied to assess gender differences. Of the cases examined, 1977 were OMF. Female victims, aged 20-59, dark-skinned, without a partner and maids were the most affected. Ecchymosis-type lesions, in the mouth and lip regions arising from the use of blunt instruments, causing permanent functional impairment, were the most prevalent in women (P < 0.05), whereas dental fracture and contusion arising from sharp instruments causing permanent deformity, occupational disability, and threat to life were detected in men (P < 0.05). The conclusion drawn is that the incidence of OMF due to physical aggression is high in São Luís, state of Maranhão, and although women are the most affected, the OMF in men are more severe.

Association between socioeconomic factors, behavioral, general health and oral mucosa status in elderly. / Associação entre fatores socioeconômicos, comportamentais, saúde geral e condição da mucosa bucal em idosos.

This study aimed to investigate the association between socioeconomic and behavioral factors, general health, oral health, and plaque accumulation and oral mucosa condition outcomes in the elderly. This is a cross-sectional study conducted from 2004 to 2005 with 785 elderly dwellers of the city of Carlos Barbosa (RS), Brasil. We used questionnaires to collect socioeconomic, behavior and health status data. The physical examination of the oral structures comprised the Mucosal-Plaque Index proposed by Henriksen (MPS). A higher prevalence of moderate/severe plaque accumulation was observed in the elderly group, in less educated male elderly. The use of full upper dentures and income under one minimum wage were protective factors for moderate/severe plaque accumulation. Only the variables of the first block of the conceptual structure, male gender (OR = 2.13; 95% CI 1.26-3.61) and lower education (OR = 1.37; 95% CI 1.06-1.78) remained associated with an unacceptable MPS score. The findings suggest that, as per MPS, less educated male elderly are more likely to have poor oral health.

O objetivo deste estudo foi investigar a associação entre fatores socioeconômicos, comportamentais, saúde geral, saúde bucal e os desfechos de acúmulo de placa e condição de mucosa bucal em idosos. Este estudo transversal, conduzido entre 2004 e 2005, incluiu 785 idosos de Carlos Barbosa, RS. Questionários foram utilizados para coleta de dados socioeconômicos, comportamentais e estado de saúde. O exame físico das estruturas bucais e o Índice de Mucosa e de Placa de Henriksen (MPS) foram utilizados para categorizar os desfechos. Observou-se maior prevalência de acúmulo de placa moderado/grave entre os idosos mais velhos, do sexo masculino e com menor escolaridade. O uso de prótese dental total superior e renda de até 1 salário mínimo foram fatores de proteção para acúmulo de placa moderado/grave. Apenas as variáveis do primeiro bloco da estrutura conceitual, sexo masculino (OR = 2,13; IC95% = 1,26-3,61) e menor escolaridade (OR = 1,37; IC95% = 1,06-1,78) permaneceram associados como risco à presença de escore inaceitável do MPS. Os achados sugerem que idosos do sexo masculino e com menor escolaridade têm maior chance de saúde bucal precária, conforme o MPS.

Location of the course of the mandibular canal, anterior loop and accessory mental foramen through cone-beam computed tomography.

PURPOSE: This study aimed at identifying the course of the mandibular canal, the presence of anterior loop and accessory mental foramen, as well as verifying the association between these variables through the analysis of cone beam computed tomography (CBCT) exams. METHODS: CBCT images were analyzed to identify the type of mandibular canal path, classified into three types: (I) catenary; (II) progressive descending; and (III) straight. In addition, the presence of anterior loop and accessory mental foramen was analyzed. The variables were summarized by measures of absolute frequency, relative, mean and standard deviation. The Chi square and Fisher's exact tests were used in the comparative analysis of the frequency distribution. The level of significance was 5%. RESULTS: The most frequent mandibular canal course was straight type (74.4%), followed by catenary (19.4%) and finally the progressive descending (6.2%). It was observed a prevalence of 10.2% for anterior loop and 7.9% for accessory mental foramen. There was no association between the presence of anterior loop (P = 0.798) and accessory mental foramen (P 0.480) with the mandibular canal course pattern, as well as no association between the anterior loop and the presence of the accessory mental foramen (P = 0.407). CONCLUSIONS: The CBCT analysis is the best methodology for the investigation and localization of mandibular anatomical variations, which provides a good image quality of the bone tissue and details of the anatomical structures, reducing the risk of injury to the lower alveolar vascular-nervous bundle and, consequently, cause paralysis and hemorrhage in the anterior region of the mandible and adjacent structures.

Oral infection by Pseudomonas aeruginosa in patient with chronic kidney disease - a case report.

Chronic renal patients are more susceptible to hospital complications and infections such as urinary tract infections, peritonitis, surgery infections, and bacteremia, which are often caused by Pseudomonas aeruginosa. A case of a HIV-positive girl with chronic kidney disease and with serious oral lesions due to P. aeruginosa septic shock is presented. The patient showed necrotic lesions in the oral mucosa, pathological tooth mobility, bone loss, and hematogenous osteomyelitis in the maxilla. The patient was submitted to systemic antibiotic therapy based on screening culture and treatment of bone lesions by eliminating the causal agent and restoring health conditions. This case report is extremely important for health professionals, since the oral cavity can be affected by this pathogen or serve as a colonization site.

Oral infection by Pseudomonas aeruginosa in patient with chronic kidney disease - a case report / Infecção oral por Pseudomonas aeruginosa em paciente com doença renal crônica - um relato de caso

ABSTRACT Chronic renal patients are more susceptible to hospital complications and infections such as urinary tract infections, peritonitis, surgery infections, and bacteremia, which are often caused by Pseudomonas aeruginosa. A case of a HIV-positive girl with chronic kidney disease and with serious oral lesions due to P. aeruginosa septic shock is presented. The patient showed necrotic lesions in the oral mucosa, pathological tooth mobility, bone loss, and hematogenous osteomyelitis in the maxilla. The patient was submitted to systemic antibiotic therapy based on screening culture and treatment of bone lesions by eliminating the causal agent and restoring health conditions. This case report is extremely important for health professionals, since the oral cavity can be affected by this pathogen or serve as a colonization site.

RESUMO Pacientes renais crônicos são mais suscetíveis a complicações e infecções hospitalares, tais como infecções do trato urinário, peritonite, infecções cirúrgicas e bacteremia, muitas vezes causadas por Pseudomonas aeruginosa. O presente relato apresenta o caso de uma menina HIV-positiva com doença renal crônica e lesões orais graves devido a choque séptico por P. aeruginosa. A paciente apresentava lesões necróticas na mucosa oral, mobilidade dentária patológica, perda óssea e osteomielite hematogênica maxilar. A paciente foi submetida a antibioticoterapia sistêmica com base na cultura de triagem e tratamento das lesões ósseas por meio da eliminação do agente causal e restauração das condições de saúde. Este relato de caso é extremamente importante para os profissionais da saúde, uma vez que a cavidade oral pode ser afetada por este patógeno ou servir como local de colonização.

Principais manifestações bucais em pacientes pediátricos HIV positivos e o efeito da terapia antirretroviral altamente ativa / Most common oral manifestations in pediatric patients HIV positive and the effect of highly active antiretroviral therapy

Resumo Esta revisão integrativa da literatura tem por objetivo identificar as principais lesões bucais que afetam pacientes pediátricos com HIV, bem como descrever o efeito da terapia antirretroviral altamente ativa (HAART) sobre essas lesões, comparando-a com a terapia antirretroviral (ART). Foi feita uma busca nas bases de dados PubMed e Scielo, seguindo critérios de inclusão e exclusão pré-determinados. Foram selecionados dezenove artigos científicos e extraídas as informações principais sobre prevalência e a frequência das manifestações bucais em pacientes pediátricos HIV positivos e o efeito da terapêutica aplicada. As lesões mais frequentes foram candidíase oral, gengivite, aumento das parótidas e eritema gengival linear. O uso da HAART mostrou diminuir a prevalência das manifestações bucais nos pacientes pediátricos com HIV e ser mais eficaz que a ART. Os achados deste estudo sugerem que a manifestação bucal mais frequente em pacientes pediátricos com HIV é a candidíase oral, seguida de alterações como gengivite e aumento das glândulas parótidas. O uso de HAART parece reduzir a prevalência dessas lesões orais, apresentando resultados mais eficazes que os da ART.

Abstract This integrative literature review aims to identify the main oral lesions affecting pediatric patients with HIV, and describe the effect of highly active antiretroviral therapy (HAART) on these injuries, comparing it to antiretroviral therapy (ART). A search was conducted in PubMed and Scielo databases, following predetermined inclusion and exclusion criteria. 19 papers were selected and the main information on the prevalence and frequency of oral manifestations in HIV-positive pediatric patients and effect of therapy applied were extracted. The most frequent injuries were oral candidiasis, gingivitis, parotid gland enlargement and linear gingival erythema. The use of HAART shown to reduce the prevalence of oral manifestations in pediatric patients with HIV and be more effective than ART. The findings of this study suggest that the most frequent oral manifestation in HIV-infected children is oral candidiasis, followed by changes such as gingivitis and enlargement parotid glands. The use of HAART appears to reduce the prevalence of these oral lesions, showing more effective results than ART.

Most common oral manifestations in pediatric patients HIV positive and the effect of highly active antiretroviral therapy. / Principais manifestações bucais em pacientes pediátricos HIV positivos e o efeito da terapia antirretroviral altamente ativa.

This integrative literature review aims to identify the main oral lesions affecting pediatric patients with HIV, and describe the effect of highly active antiretroviral therapy (HAART) on these injuries, comparing it to antiretroviral therapy (ART). A search was conducted in PubMed and Scielo databases, following predetermined inclusion and exclusion criteria. 19 papers were selected and the main information on the prevalence and frequency of oral manifestations in HIV-positive pediatric patients and effect of therapy applied were extracted. The most frequent injuries were oral candidiasis, gingivitis, parotid gland enlargement and linear gingival erythema. The use of HAART shown to reduce the prevalence of oral manifestations in pediatric patients with HIV and be more effective than ART. The findings of this study suggest that the most frequent oral manifestation in HIV-infected children is oral candidiasis, followed by changes such as gingivitis and enlargement parotid glands. The use of HAART appears to reduce the prevalence of these oral lesions, showing more effective results than ART.

Esta revisão integrativa da literatura tem por objetivo identificar as principais lesões bucais que afetam pacientes pediátricos com HIV, bem como descrever o efeito da terapia antirretroviral altamente ativa (HAART) sobre essas lesões, comparando-a com a terapia antirretroviral (ART). Foi feita uma busca nas bases de dados PubMed e Scielo, seguindo critérios de inclusão e exclusão pré-determinados. Foram selecionados dezenove artigos científicos e extraídas as informações principais sobre prevalência e a frequência das manifestações bucais em pacientes pediátricos HIV positivos e o efeito da terapêutica aplicada. As lesões mais frequentes foram candidíase oral, gengivite, aumento das parótidas e eritema gengival linear. O uso da HAART mostrou diminuir a prevalência das manifestações bucais nos pacientes pediátricos com HIV e ser mais eficaz que a ART. Os achados deste estudo sugerem que a manifestação bucal mais frequente em pacientes pediátricos com HIV é a candidíase oral, seguida de alterações como gengivite e aumento das glândulas parótidas. O uso de HAART parece reduzir a prevalência dessas lesões orais, apresentando resultados mais eficazes que os da ART.